Today I've read an excellent article written by Jimmy Nilsson about The Cost of GUIDs as Primary Keys. A must-read article when your using GUIDs as primary keys in your database.
I must admit that I have been always against using GUIDs as a primary key because of the bad performance you get when having tables with lots of records. After reading this article, I believe that COMBs will solve this issue.
PS: I can strongly recommend you to get a copy of Applying Domain-Driven Design and Patterns. Two thumbs up!